Cell-Penetrating Peptides: Applications in Tumor Diagnosis and Therapeutics
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چکیده
منابع مشابه
Cell-Penetrating Peptides— Uptake, Toxicity, and Applications
Cell-penetrating peptides (CPPs) mediate the uptake of interconnected cargoes of different types into cells and organisms. Studies in living cells revealed that high-molecular-weight cargoes linked to CPPs are delivered via endocytic routes whereas CPPs by themselves or fused to low-molecular-weight cargoes can in addition enter by a mechanism that does not require vesicle formation. This latte...
متن کاملCell-penetrating peptides and their therapeutic applications
The process of introducing drugs into cells has always proved a major challenge for research scientists and for the pharmaceutical industry. The cell membrane is selectively permeable and supports no generic mechanism for their uptake. A drug must be either highly lipophilic or very small to stand a chance of cellular internalization. These restrictions mean that the repertoire of possible drug...
متن کاملTumor-Penetrating Peptides
Tumor-homing peptides can be used to deliver drugs into tumors. Phage library screening in live mice has recently identified homing peptides that specifically recognize the endothelium of tumor vessels, extravasate, and penetrate deep into the extravascular tumor tissue. The prototypic peptide of this class, iRGD (CRGDKGPDC), contains the integrin-binding RGD motif. RGD mediates tumor-homing th...
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The field of gene therapy is starting to move towards clinical applications but is currently limited by the lack of efficient delivery systems. Cell-penetrating peptides provide a means of cellular delivery for gene therapy applications as well as delivery of traditional drugs. Using cell-penetrating peptides a range of different cargoes have been successfully delivered into a number of cell ty...
متن کاملRational modifications of cell-penetrating peptides for drug delivery Applications in tumor targeting and oligonucleotide delivery
High molecular weight biomolecules are becoming increasingly important in the development of new therapeutics. However, the hydrophilic nature and size of such molecules creates a major limitation for their application – poor penetration through biological membranes. Over a decade ago, a new class of peptides, cell-penetrating peptides (CPPs), with membrane translocating ability, was discovered...
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ژورنال
عنوان ژورنال: Pharmaceutics
سال: 2021
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics13060890